Single-step radiofluorination of peptides using continuous flow microreactor.

نویسندگان

  • Svetlana V Selivanova
  • Linjing Mu
  • Johanna Ungersboeck
  • Timo Stellfeld
  • Simon M Ametamey
  • Roger Schibli
  • Wolfgang Wadsak
چکیده

18F radiolabelling of peptides bearing two different prosthetic groups was successfully conducted in a continuous flow microfluidic device for the first time. Radiochemical yields were dependent on precursor concentration, reaction temperature and flow rate. The choice of leaving group had a dramatic influence on the reaction outcome. Rapid reaction optimization was possible.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 10 19  شماره 

صفحات  -

تاریخ انتشار 2012